Crystal structure of the Fc fragment of PF06438179/GP1111 an infliximab biosimilar in a primative orthorhombic crystal form, Lot A
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Crystal structure of the Fc fragment of PF06438179/GP1111 an infliximab biosimilar in a primative orthorhombic crystal form, Lot A Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... Authors: Mayclin, S.J, Edwards, T.E. Deposit date: 2019-09-26 Release date: 2019-11-13 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Crystal Structures of PF-06438179/GP1111, an Infliximab Biosimilar. BioDrugs, 34, 2020
英夫利昔单抗生物类似药PF06438179/GP1111的Fc段（Fc fragment）晶体结构，采用原始斜方晶系结晶，批次为A批次。A批次特征：2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖（2-acetamido-2-deoxy-beta-D-glucopyranose）-(1→2)-α-D-吡喃甘露糖（alpha-D-mannopyranose）-(1→3)-[2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖（2-acetamido-2-deoxy-beta-D-glucopyranose）-(1→2)-α-D-吡喃甘露糖（alpha-D-mannopyranose）-(1→6)]-β-D-吡喃甘露糖（beta-D-mannopyranose）-(1→4)-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖（2-acetamido-2-deoxy-beta-D-glucopyranose）-(1→4)-[α-L-吡喃岩藻糖（alpha-L-fucopyranose）-(1→6)]-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖（2-acetamido-2-deoxy-beta-D-glucopyranose）、2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖（2-acetamido-2-deoxy-beta-D-glucopyranose）-(1→2)-α-D-吡喃甘露糖（alpha-D-mannopyranose）-(1→6)-[α-D-吡喃甘露糖（alpha-D-mannopyranose）-(1→3)]-β-D-吡喃甘露糖（beta-D-mannopyranose）-(1→4)-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖（2-acetamido-2-deoxy-beta-D-glucopyranose）-(1→4)-[α-L-吡喃岩藻糖（alpha-L-fucopyranose）-(1→6)]-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖（2-acetamido-2-deoxy-beta-D-glucopyranose）、氯离子（CHLORIDE ION）等。
作者：Mayclin S.J.、Edwards T.E.
提交日期：2019-09-26
发布日期：2019-11-13
最后修改日期：2024-10-30
解析方法：X射线衍射法（分辨率2.1埃）
引用文献：《英夫利昔单抗生物类似药PF-06438179/GP1111的晶体结构》，《生物药物》，2020年，第34卷
创建时间：
2019-09-26
