Table_1_Prevalence and prognosis of acute ischemic stroke coexisting with unruptured intracranial aneurysms.docx

ObjectivesThe prevalence of unruptured intracranial aneurysms (UIAs) in the acute ischemic stroke (AIS) cohort is probably higher than in the general population. This study investigated the prevalence of UIAs in AIS patients and the management risk and prognosis when treating AIS.MethodsFrom January 2020 to January 2023, we conducted a single-center retrospective study at Tianjin Huanhu Hospital. Each patient underwent both brain MRI and MRA/CTA to diagnose AIS and UIAs. Clinical, radiologic, and therapeutic data during hospitalization and prognosis were analyzed. Propensity-score matching (PSM) was performed to evaluate the risk of in-hospital adverse events, unfavorable outcomes at discharge when receiving post-stroke treatment and stroke recurrence.ResultsIn all, 2,181 AIS patients were included, of whom 270 had UIAs (12.4%; 95%CI 11.0–13.8%). From the unmatched and matched cohort, the incidence of in-hospital adverse events and unfavorable outcomes at discharge in patients with UIAs were not significantly different; the risk of stroke recurrence was significantly higher in patients with UIAs than in those without (unmatched: aHR, 1.71 [1.08–2.70]; matched: aHR, 2.55 [1.16–5.58]). Multivariable Cox regression models showed that aneurysm size and the presence of homoregional infarction associated with higher risk of recurrence (unmatched: aHR, 1.31 [1.21–1.41] and aHR, 3.50 [1.52–8.10]; matched: aHR, 1.28 [1.18–1.40]; p

研究目标：在急性缺血性卒中（AIS）队列中，未破裂颅内动脉瘤（UIAs）的患病率可能高于普通人群。本研究旨在探讨AIS患者中UIAs的患病率，以及治疗AIS时的管理风险及预后。研究方法：自2020年1月至2023年1月，我们在天津环湖医院进行了一项单中心回顾性研究。每位患者均接受了脑MRI和MRA/CTA检查以诊断AIS和UIAs。分析了住院期间的临床、影像和治疗数据，以及预后情况。采用倾向评分匹配（PSM）方法评估住院不良事件的风险、接受卒中后治疗时的出院不良预后以及卒中复发风险。研究结果：共纳入2,181例AIS患者，其中270例患有UIAs（12.4%；95%CI 11.0–13.8%）。在未匹配和匹配队列中，UIAs患者的住院不良事件发生率和出院不良预后率并无显著差异；与无UIAs的患者相比，UIAs患者的卒中复发风险显著更高（未匹配：调整后风险比aHR，1.71 [1.08–2.70]；匹配：调整后风险比aHR，2.55 [1.16–5.58]）。多变量Cox回归模型显示，动脉瘤大小以及同侧区域梗死的存在与更高的复发风险相关（未匹配：调整后风险比aHR，1.31 [1.21–1.41]和aHR，3.50 [1.52–8.10]；匹配：调整后风险比aHR，1.28 [1.18–1.40]；p值...）。