Statistics for mixed models implementing RMANOVA.

Models were implemented in the SAS procedure proc mixed [42]. Repeated measures were across time-points, with subject as a random factor. The overall model fit is reported as ChiSquare and p value. For significant overall models (which were all for this data set), variables were tested individually, demonstrating significant time and group-by-time effects in all cases (F statistic and p value reported). Significant within and between group differences at individual time-points are shown in Figs. 1, 3 & 5.