Data for: THE POSTERIOR INSULAR CORTEX IS NECESSARY FOR THE CONSOLIDATION OF TONE FEAR CONDITIONING

Data obtained from the study "THE POSTERIOR INSULAR CORTEX IS NECESSARY FOR THE CONSOLIDATION OF TONE FEAR CONDITIONING". Here we verified the effects of temporary functional inactivation of the anterior (aIC) and posterior IC (pIC) on contextual and tone fear memory. Rats received post-training bilateral infusions of the GABAA receptor agonist muscimol into either the aIC or pIC and were tested 48 and 72 hours after the conditioning session to assess contextual (CFC) and tone (TFC) fear conditioning, respectively. Inactivation of the aIC during memory consolidation did not affect fear memory for CFC or TFC. On the other hand, post-training inactivation of the pIC impaired TFC but not CFC. Our findings indicate that the pIC is a necessary part of the neural circuitry related to the consolidation of cued-fear memories.本数据集源自题为《后岛叶皮层是音调恐惧条件反射巩固所必需的》的研究。本研究验证了前岛叶（aIC, anterior insular cortex）与后岛叶（pIC, posterior insular cortex）的暂时性功能失活对情境性恐惧记忆与音调性恐惧记忆的影响。实验大鼠于训练后分别向双侧前岛叶或双侧后岛叶输注γ-氨基丁酸A型（GABAA）受体激动剂蝇蕈醇（muscimol），并于条件反射训练后48小时与72小时依次接受情境性恐惧条件反射（CFC）与音调性恐惧条件反射（TFC）测试，以评估相关记忆水平。记忆巩固阶段对前岛叶的功能失活，并未对情境性或音调性恐惧记忆产生影响。与之相反，训练后对后岛叶的功能失活会损伤音调性恐惧记忆，但对情境性恐惧记忆无显著影响。本研究结果表明，后岛叶是与线索性恐惧记忆巩固相关的神经环路中不可或缺的组成部分。