Relationship of miR-146a level and clinicopathological variables in lung cancer tissues.

aFISH negative with no or low genomic gain (≤four copies of gene in >40% of the cells) and FISH positive with gene amplification, defined by the presence of tight gene clusters, a gene/chromosome per cell ratio ≥2, or ≥15 copies of the genes per cell in ≥10% of the analyzed cells or with high polysomy (≥four copies of the gene in ≥40% of the cells). Eight cases had high polysomy and one case had gene amplification. Information for the different variables was not available for all cases in this retrospective series.bFive cases had E746-A750 deletion (exon 19) and one case had L858R point mutation (exon 21).