Regulating stem cell-related genes induces the plastic differentiation of cancer stem cells to treat cancer

NIAID Data Ecosystem2026-03-12 收录

癌症干细胞分化

基因治疗调控

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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE115809 数据链接链接失效反馈

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This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

创建时间：

2021-06-14

The inhibition of KDM2B promotes the differentiation of basal-like breast cancer cells via the posttranslational destabilization of SLUG

癌症干细胞分化

组蛋白去甲基化

KDM2B is a JmjC domain H3K36me2/H3K36me1 demethylase, which immortalizes cells in culture and contributes to the biology of both embryonic and adult stem and progenitor cells. It also functions as an

NIAID Data Ecosystem70

Dynamic activation of rAAV transgene expression by a small molecule that recruits endogenous transcriptional machinery

基因治疗调控

表观基因组学

The silencing of adeno-associated virus (AAV) vectors over time poses a challenge to the development of effective gene therapies. Here, we describe a bioorthogonal platform for tuning AAV expression,

NIAID Data Ecosystem50

Regulating stem cell-related genes induces the plastic differentiation of cancer stem cells to treat cancer. Regulating stem cell-related genes induces the plastic differentiation of cancer stem cells to treat cancer

癌症干细胞分化

基因治疗调控

This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

NIAID Data Ecosystem50

Embryonic Carcinoma Cells Show Specific Dielectric Resistance Profiles during Induced Differentiation

癌症干细胞分化

介电抗性分析

Induction of differentiation in cancer stem cells by drug treatment represents an important approach for cancer therapy. The understanding of the mechanisms that regulate such a forced exit from malig

NIAID Data Ecosystem60

Merkel cell polyomavirus pan-T antigen knockdown reduces cancer cell stemness and promotes neural differentiation independent of RB1

病毒致癌机制

癌症干细胞分化

Merkel cell carcinoma (MCC) is a highly aggressive skin cancer associated with integration of Merkel cell polyomavirus (MCPyV). MCPyV-encoded T-antigens (TAs) are pivotal for sustaining MCC’s oncogeni

NIAID Data Ecosystem50

Regulating stem cell-related genes induces the plastic differentiation of cancer stem cells to treat cancer

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