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Modification of PCNA by ISG15 Plays a Crucial Role in PDCoV Infection

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To clarify the novel roles of ISG15 during PDCoV infection, we constructed a stably ISG15-overexpressed IPEC-J2 cell line and employed affinity pulldown and quantitative LC-MS/MS analyses with ISG15, enabling the identification of 350 known and novel candidate ISGylation proteins as well as protein complexes.

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2025-03-27
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