Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the Methyl(phenyl)amino-substituted Estrogen, (8R,9S,13S,14S,17S)-13-methyl-17-(methyl(phenyl)amino)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-ol

Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the Methyl(phenyl)amino-substituted Estrogen, (8R,9S,13S,14S,17S)-13-methyl-17-(methyl(phenyl)amino)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-ol Descriptor: (8~{R},9~{S},13~{S},14~{S},17~{S})-13-methyl-17-[methyl(phenyl)amino]-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-ol, Estrogen receptor, NCOA2 Authors: Nwachukwu, J.C, Srinivasan, S, Bruno, N.E, Nowak, J, Kojetin, D.J, Elemento, O, Katzenellenbogen, J.A, Nettles, K.W. Deposit date: 2016-07-07 Release date: 2017-01-18 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies. Cell Chem Biol, 24, 2017

雌激素受体α（ER-α）配体结合域（Y537S）与甲基(苯基)氨基取代雌激素(8R,9S,13S,14S,17S)-13-甲基-17-(甲基(苯基)氨基)-7,8,9,11,12,13,14,15,16,17-十氢-6H-环戊并[a]菲-3-醇的复合物晶体结构
描述物：(8R,9S,13S,14S,17S)-13-甲基-17-[甲基(苯基)氨基]-6,7,8,9,11,12,14,15,16,17-十氢环戊并[a]菲-3-醇、雌激素受体、核受体辅激活因子2（NCOA2）
作者：Nwachukwu, J.C、Srinivasan, S、Bruno, N.E、Nowak, J、Kojetin, D.J、Elemento, O、Katzenellenbogen, J.A、Nettles, K.W.
沉积日期：2016-07-07
发布日期：2017-01-18
最后修改日期：2024-03-06
实验方法：X射线衍射（2.1 Å）
引用文献：《配体对ER-α影响的系统结构生物学分析可预测环境雌激素与抗激素治疗的细胞应答》，《细胞化学生物学》，24卷，2017年