RNAseq data on L6 myotube treated with eicosapentaenoic acid and GW501516

We found that dietary eicosapentaenoic acid (EPA), a unique fatty acid in fish oil, promotes whole-body oxidative metabolism and improves muscle function by increasing slow-twitch fiber formation in rats. To identify the pathways activated after treatment with EPA or GW501516 (a PPARdelta selective agonist), we comprehensively analyzed mRNA expression levels in differentiated L6 myotubes. This study provides a new insight which the development of muscle-targeted exercise mimetics food may contribute to a pharmaceutical alternative for the management of an increasingly sedentary lifestyle.