Alliance of Genome Resources

The primary mission of the Alliance of Genome Resources (the Alliance) is to develop and maintain sustainable genome information resources that facilitate the use of diverse model organisms in understanding the genetic and genomic basis of human biology, health and disease. This understanding is fundamental for advancing genome biology research and for translating human genome data into clinical utility.
The unified Alliance information system will represent the union of the data and information represented in the current individual MODs rather than the intersection, and thus provide the best of each in one place while maintaining community integrity and preserving the unique aspects of each model organism. By working together we can be more comprehensive and efficient, and hence more sustainable. Through the implementation of a shared, modular information system architecture, the Alliance seeks to serve diverse user communities including (i) human geneticists who want access to all model organism data for orthologous human genes; (ii) basic science researchers who use specific model organisms to understand fundamental biology; (iii) computational biologists and data scientists who need access to standardized, well-structured data, both big and small; and (iv) educators and students.
Community genome resources such as the Model Organism Databases and the Gene Ontology Consortium have developed high quality resources enabling cost and time effective information retrieval and aggregation that would otherwise require countless hours to achieve. Regardless of their success and utility, there remain challenges to using and sustaining MODs. Searching across multiple model organism database resources remains a barrier to realizing the full impact of these resources in advancing genome biology and genomic medicine. In addition, despite a growing need for MODs by the biomedical research community as well as the increasing volumes of data and publications, the financial resources available to sustain MODs and related information resources are being reduced. We believe that one contribution to solving these challenges while continuing to serve our diverse user communities is to unify our efforts. To this end, six MODs (Saccharomyces Genome Database, WormBase, FlyBase, Zebrafish Information Network, Mouse Genome Database, Rat Genome Database) and the Gene Ontology (GO) project joined together in the fall of 2016 to form the Alliance of Genome Resources (the Alliance) consortium. Resources in this dataset:Resource Title: Alliance of Genome Resources. File Name: Web Page, url: https://www.alliancegenome.org/

基因组资源联盟（以下简称联盟）的主要使命是开发并维护可持续的基因组信息资源，以促进多种模式生物在理解人类生物学、健康与疾病遗传和基因组基础方面的应用。这种理解对于推进基因组生物学研究并将人类基因组数据转化为临床效用至关重要。统一的联盟信息系统将体现当前各独立模式生物数据库（MODs）所代表的数据和信息的融合，而非交集，从而在保留社区完整性并维护各模式生物独特性的同时，将各数据库的优势汇聚一处。通过协同合作，我们能够实现更全面的效率和更高的可持续性。通过实施共享的、模块化的信息系统架构，联盟旨在服务于多元化的用户群体，包括：（一）希望访问所有模式生物数据以研究同源人类基因的人类遗传学家；（二）利用特定模式生物来研究基础生物学的自然科学研究者；（三）需要访问标准化、结构良好的数据的计算生物学家和数据科学家，无论是大数据还是小数据；（四）教育者和学生。诸如模式生物数据库和基因本体学联盟等社区基因组资源已开发出高质量的资源，使得成本和时间的有效信息检索和聚合成为可能，否则这将需要无数小时的工作。尽管这些资源在成功和实用性方面取得了显著成果，但在使用和维持MODs方面仍然存在挑战。在多个模式生物数据库资源之间进行搜索仍然是实现这些资源在推进基因组生物学和基因组医学方面全部影响的一个障碍。此外，尽管生物医学研究社区对MODs的需求日益增长，数据量和出版物也在不断增加，但可用于维持MODs和相关信息资源的财务资源却在减少。我们认为，为了解决这些挑战并继续服务于我们多元化的用户群体，统一我们的努力是一个重要贡献。为此，六个MODs（包括酵母基因组数据库、线虫数据库、果蝇数据库、斑马鱼信息网络、小鼠基因组数据库和 Rat Genome Database）以及基因本体学（GO）项目在2016年秋季联合起来，形成了基因组资源联盟（以下简称联盟）联盟。本数据集包含的资源：资源标题：基因组资源联盟。文件名：网页，网址：https://www.alliancegenome.org/