Expression data in the cerebral cortex of postnatal Dyrk1a+/+ and Dyrk1a+/- mice. Expression data in the cerebral cortex of postnatal Dyrk1a+/+ and Dyrk1a+/- mice

DYRK1A is a protein kinase with several roles in brain development. This kinase is involved in two intellectual disability syndromes: Down syndrome and DYRK1A haploinsufficiency syndrome. The Dyrk1a+/- mouse is a model for DYRK1A haploinsufficiency syndrome. We used microarray to evaluate the impact of DYRK1A haploinsufficiency in the development of the cerebral cortex. Overall design: Total RNA was prepared from the cerebral cortex of 4 Dyrk1a+/+ and 4 Dyrk1a+/- mice at both P0 and P7 for hybridization on Affymetrix Mouse GeneChip 430 2.0 Array.