ULTRAVIOLET RADIATION AS A MODULATOR OF INFLAMMATORY AND IMMUNE RESPONSES IN PURULENT-INFECTIOUS PATHOLOGY: MECHANISTIC FOUNDATIONS AND CLINICAL IMPLICATIONS

Purulent-inflammatory diseases remain a complex clinical problem characterized by persistent microbial contamination, dysregulated immune reactions, impaired microcirculation, and delayed reparative processes. In the context of escalating antimicrobial resistance, non-pharmacological adjunctive strategies capable of pathogenetic modulation are attracting increasing scientific attention. Ultraviolet radiation (UVR), as a biologically active electromagnetic factor, induces a spectrum of photochemical and immunobiological responses that may influence the course of inflammatory pathology. This analytical review synthesizes current experimental and clinical evidence regarding spectral characteristics, molecular targets, immunoregulatory mechanisms, and antimicrobial properties of UVR. Particular emphasis is placed on dose-dependent biological responses, systemic microcirculatory modulation, and the integration of ultraviolet-based approaches into complex therapeutic protocols. The necessity for standardized dosimetry, objective immunomorphological assessment, and evidence-based safety criteria is critically discussed. Ultraviolet radiation demonstrates potential as a controlled adjunctive modality in purulent-inflammatory diseases; however, its broader clinical implementation requires rigorous methodological validation and harmonized therapeutic algorithms.