G-quadruplexes as pivotal components of cis-regulatory elements in the human genome

This repository stores the scripts for analyzing the relationship between G-quadruplexes (G4s) and cis-regulatory elements (CREs), as well as the data generated directly from the manuscript.

Manuscript: G-quadruplexes as pivotal components of cis-regulatory elements in the human genome

G4Hunter_w25_s1.5_hg38.txt: All potential G-quadruplexes in the human genome predicted by the G4Hunter software. 

Genome assembly: hg38.

G4Hunter software parameters were set as follows: score threshold 1.5, window size 25.

G4_cCRE_annotation.txt: Annotation file indicating the presence of G4s in cCREs (candidate CREs; from SCREEN database).

scripts.zip: Source code used for data analysis in this project, based on the R language.