Candida glabrata Dihydrofolate Reductase complexed with 2,4-diamino-5-[3-methyl-3-(3-methoxy-5-(3,5-dimethylphenyl)phenyl)prop-1-ynyl]-6-methylpyrimidine(UCP11153TM) and NADPH

Candida glabrata Dihydrofolate Reductase complexed with 2,4-diamino-5-[3-methyl-3-(3-methoxy-5-(3,5-dimethylphenyl)phenyl)prop-1-ynyl]-6-methylpyrimidine(UCP11153TM) and NADPH Descriptor: 5-[(3R)-3-(5-methoxy-3',5'-dimethylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine, Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Liu, J, Anderson, A. Deposit date: 2008-09-04 Release date: 2009-08-18 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Probing the active site of Candida glabrata dihydrofolate reductase with high resolution crystal structures and the synthesis of new inhibitors Chem.Biol.Drug Des., 73, 2009

本数据集为光滑念珠菌（Candida glabrata）二氢叶酸还原酶（Dihydrofolate Reductase）与配体2,4-二氨基-5-[3-甲基-3-(3-甲氧基-5-(3,5-二甲基苯基)苯基)丙-1-炔基]-6-甲基嘧啶（UCP11153TM）及烟酰胺腺嘌呤二核苷酸磷酸（NADPH）形成的复合物。相关描述符包括：5-[(3R)-3-(5-甲氧基-3',5'-二甲基联苯-3-基)丁-1-炔-1-基]-6-甲基嘧啶-2,4-二胺、二氢叶酸还原酶、烟酰胺腺嘌呤二核苷酸磷酸（NADPH）。作者：Liu J、Anderson A.。存入日期：2008年9月4日，发布日期：2009年8月18日，最后修改日期：2024年2月21日。实验方法为X射线衍射（分辨率1.95埃）。引用文献：《通过高分辨率晶体结构探究光滑念珠菌二氢叶酸还原酶的活性位点并合成新型抑制剂》，刊载于《Chem.Biol.Drug Des.》（化学生物学与药物设计）2009年第73卷。