Targeted next-generation sequencing of 13 chordoid gliomas of the third ventricle

Chordoid glioma is a rare brain tumor thought to arise from specialized ependymal cells of the lamina terminalis along the anterior wall of the third ventricle. We performed targeted next-generation sequencing of approximately 500 cancer-associated genes on a cohort of 13 chordoid gliomas and identified a recurrent D463H missense mutation in the PRKCA gene in all tumors, which localizes in the kinase domain of the encoded protein kinase C alpha (PKCa).EGA study EGAS00001002733