Crystal Structure of Human DPP4 Bound to TAK-100

Crystal Structure of Human DPP4 Bound to TAK-100 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Yano, J.K, Aertgeerts, K. Deposit date: 2010-08-03 Release date: 2011-01-26 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Discovery of a 3-Pyridylacetic Acid Derivative (TAK-100) as a Potent, Selective and Orally Active Dipeptidyl Peptidase IV (DPP-4) Inhibitor. J.Med.Chem., 53, 2011人二肽基肽酶IV（DPP-4）结合TAK-100的晶体结构及配体描述：2-乙酰胺基-2-脱氧-β-D-吡喃葡萄糖、2-乙酰胺基-2-脱氧-β-D-吡喃葡萄糖-(1→4)-2-乙酰胺基-2-脱氧-β-D-吡喃葡萄糖、2-乙酰胺基-2-脱氧-β-D-吡喃葡萄糖-(1→4)-2-乙酰胺基-2-脱氧-β-D-吡喃葡萄糖-(1→4)-2-乙酰胺基-2-脱氧-β-D-吡喃葡萄糖…… 作者：Yano, J.K.、Aertgeerts, K. 提交日期：2010-08-03 发布日期：2011-01-26 最后修改日期：2024-10-16 实验方法：X射线衍射（分辨率2.85 Å） 引用文献：《3-吡啶乙酸衍生物（TAK-100）作为强效、选择性且口服有效的二肽基肽酶IV（DPP-4）抑制剂的发现》，《J.Med.Chem.》，53卷，2011年