Physicochemical properties of nanoparticles loaded with anti-HIV agents.

aEfavirenz (EFV) and Saquinavir (SQV) nanoparticles were synthesized using single emulsion and nanoprecipitation techniques, respectively.
bThe particle size, polydispersity indices (PDI) and zeta potential were determined using dynamic light scattering (DLS); data are the average of three batches.
cParticles showed two peak sizes. This number represents the average peak intensity size for three batches of SQV nanoparticles. Two of the three batches displayed bimodal size distribution with one peak ∼100–200 nm and another peak at ∼600–2500 nm. Since the large peaks are likely indicative of aggregated clumps of particles and not individual particles, these large peaks were not included in the average size shown here but still affect the PDI value.