Telomeric DNA damage response activation mediates idiopathic pulmonary fibrosis caused by telomere dysfunction

ChEBI2026-07-10 更新2026-07-12 收录

端粒相关疾病机制

肺纤维化病理研究

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-MTAB-14908 数据链接链接失效反馈

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资源简介：

Telomeric DNA damage response activation mediates idiopathic pulmonary fibrosis caused by telomere dysfunction

创建时间：

2026-07-10

Single-cell RNA-seq of sort human lung explants from IPF and SSc-ILD patients

单细胞转录组学

肺纤维化病理研究

To understand the cellular composition and transcriptional phenotype of fibrotic lung tissue we performed single-cell RNA-seq on stromal, immune, epithelial, and endothelial cell populations from huma

NIAID Data Ecosystem70

Single cell RNA-sequencing on healthy and IPF lung mesenchymal cells.. Single cell RNA-sequencing on healthy and IPF lung mesenchymal cells.

单细胞RNA测序

肺纤维化病理研究

Single cell lung suspensions of explanted healthy and IPF donor lung tissue were generated. scRNA-seq was performed on EPCAM negative live cells sorted by FACS. Puried mesenchymal cells were clustered

NIAID Data Ecosystem30

Domain-specific mutations in dyskerin disrupt 3´end processing of snoRNAs. Domain-specific mutations in dyskerin disrupt 3´end processing of snoRNAs

snoRNA生物合成

端粒相关疾病机制

Mutations in genes encoding components of the telomerase holoenzyme complex result in a spectrum of rare genetic disorders known as telomere diseases, including dyskeratosis congenita (DC). A consiste

NIAID Data Ecosystem20

Telomere dysfunction induces Sirtuin repression that drives telomere-dependent disease. Telomere dysfunction induces Sirtuin repression that drives telomere-dependent disease

端粒相关疾病机制

p53依赖性miRNA

We have characterized the p53-dependent miRNAs in murine liver in telomerase knckout mice with short telomeres Overall design: Identification of p53-dependent miRNAs in telomerase knockout mice with a

NIAID Data Ecosystem50

Transcriptional profiling of short telomere iPS derived sorted SFTPC+ iAT2 cells. Transcriptional profiling of short telomere iPS derived sorted SFTPC+ iAT2 cells

肺纤维化细胞模型

端粒相关疾病机制

Dyskeratosis congenita (DC) is a rare genetic disorder characterized by deficiencies in telomere maintenance leading to very short telomeres and the premature onset of certain age_Related diseases, in

NIAID Data Ecosystem20

Telomeric DNA damage response activation mediates idiopathic pulmonary fibrosis caused by telomere dysfunction

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