Endothelial TGFb signaling drives vascular inflammation and atherosclerosis [bulk RNA-Seq]

Endothelial TGFβ signaling is one of the primary drivers of atherosclerosis-associated vascular inflammation.  Inhibition of endothelial TGFβ signaling in hyperlipidemic mice reduces vessel wall inflammation and vascular permeability and leads to arrest of disease progression and regression of established lesions. We performed scRNAseq method to examine endothelial cell gene expression profile using Apoe and EC specific TGFbR1/2 KO in Apoe background mice. Examination of different cell types gene expression in response to TGFb stimulation