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CUT&Tag profiling of H3K18LA modification in rat pancreas with acute pancreatitis

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This study explores histone modification dynamics in acute pancreatitis. Sprague-Dawley rats were intraperitoneally injected twice with L-arginine (2.5 g/kg, 1-hour interval) to induce acute pancreatitis. Pancreatic tissues were harvested after 48 hours. CUT&Tag was performed using anti-H3K18LA antibody (IP) and corresponding input control to assess promoter-associated chromatin changes in the inflamed pancreas.

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