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Transcription profiling of mouse thymus in pre diabetic and diabetic state of NOD (non obese diabetic) animal strain

ChEBI2009-10-14 更新2026-07-21 收录

自身免疫性糖尿病

腺体转录组学

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-MEXP-2321 数据链接链接失效反馈

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资源简介：

Transcription profiling of mouse thymus in pre diabetic and diabetic state of NOD (non obese diabetic) animal strain

应用场景：

创建时间：

2009-10-14

自身免疫性糖尿病

单细胞转录组学

Pancreatic islet cell populations in KRV-infected LEW.1WR1 rats compared to those of controls identifies a population of "hot" endocrine cells that appear to lead to autoimmume diabetes in the infecte

NIAID Data Ecosystem70

Cytotoxic T-cell precursors with low-level CD8 in the diabetes-prone Biobreeding rat: implications for generation of an autoimmune T-cell repertoire.

自身免疫性糖尿病

细胞免疫病理学

Lymphocytes from diabetes-prone Biobreeding rats consistently fail to generate T-cell-mediated cytotoxicity under conditions where cytotoxic T lymphocyte activity is readily demonstrated in normal rat

PubMed Central40

The islet resident macrophage is in an inflammatory state and senses microbial products in blood. Mus musculus

巨噬细胞免疫

自身免疫性糖尿病

We examined the transcriptional profiles of macrophages that reside in the islets of Langerhans of NOD, NOD.Rag1-/-, and B6.g7 mice at three weeks of age. Islet macrophages expressed an activation sig

NIAID Data Ecosystem30

Dataset: The integrated stress response promotes macrophage inflammation and migration in autoimmune diabetes

自身免疫性糖尿病

巨噬细胞炎症与迁移

Type 1 diabetes (T1D) is an autoimmune disease characterized by the destruction of insulin producing pancreatic β-cells. Macrophages infiltrate islets early in T1D pathogenesis, preceding the influx o

NIAID Data Ecosystem60

Low affinity TCRs support regulatory T cell function in autoimmunity. Low affinity TCRs support regulatory T cell function in autoimmunity

自身免疫性糖尿病

调节性T细胞功能

Low affinity Tregs are important for controlling autoimmune diabetes. Overall design: High and low affinity Tregs were isolated from the spleen and pancreatic islets of two-TCR retrogenic mice express

NIAID Data Ecosystem40

Transcription profiling of mouse thymus in pre diabetic and diabetic state of NOD (non obese diabetic) animal strain

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