Single nuclei RNA-seq of brain of mouse Alzheimer's disease model
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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http://data.iscr.ac.cn/Article?id=a4642e3e562ee9fcb5abd0b2bc512195
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资源简介：
Here we report single nucleus RNA-seq shows in 5xFAD mouse model of AD and WT, showing changes in the composition and state of multiple cell types. In particular, we identified a unique population of disease-associated astrocytes (DAAs) in AD. DAAs appeared at early disease stages and increased in abundance with age. Similar cells were found in aged WT mice and human brains, suggesting they are linked to both genetic and age-related factors.
提供机构：
Hebrew University of Jerusalem
创建时间：
2022-02-20
