Exercise training attenuated the muscle mitochondria genomic response to 70 day bedrest (RNA-Seq)

The purpose of this study was to characterize the vastus lateralis (VL) gene and microRNA responses to 70 day bed rest with and without exercise countermeasures to mitigate the negative consequences of weightlessness. Gene expression profiling was determined in vastus lateralis muscle at baseline before bedrest and after ~70 days bedrest in 3 groups: a) Control group (CON), bedrest without exercise intervention; b) Exercise group (EX), bedrest and traditional exercise intervention; c) Flywheel group (FLY), bedrest and flywheel exercise intervention