Staphylococcus aureus Dihydrofolate Reductase complexed with NADPH and 6-ETHYL-5-[(3R)-3-[3-METHOXY-5-(PYRIDIN-4-YL)PHENYL]BUT-1-YN-1-YL]PYRIMIDINE-2,4-DIAMINE (UCP1061)

Protein Data Bank Japan2023-09-27 更新2026-03-21 收录

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https://pdbj.org/mine/summary/4xe6

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Staphylococcus aureus Dihydrofolate Reductase complexed with NADPH and 6-ETHYL-5-[(3R)-3-[3-METHOXY-5-(PYRIDIN-4-YL)PHENYL]BUT-1-YN-1-YL]PYRIMIDINE-2,4-DIAMINE (UCP1061) Descriptor: 6-ethyl-5-{(3R)-3-[3-methoxy-5-(pyridin-4-yl)phenyl]but-1-yn-1-yl}pyrimidine-2,4-diamine, ACETATE ION, Dihydrofolate reductase, ... Authors: Reeve, S.M, Anderson, A.C. Deposit date: 2014-12-23 Release date: 2016-01-20 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.692 Å) Cite: Stereo-selectively Induced Cofactor Switching Provides Insight into Cofactor Site Plasticity as a Possible Mechanism of Antifolate Resistance To Be Published

金黄色葡萄球菌（Staphylococcus aureus）二氢叶酸还原酶（Dihydrofolate Reductase）与烟酰胺腺嘌呤二核苷酸磷酸（NADPH）及6-乙基-5-[(3R)-3-[3-甲氧基-5-(吡啶-4-基)苯基]丁-1-炔-1-基]嘧啶-2,4-二胺（UCP1061）复合物。描述符：6-乙基-5-{(3R)-3-[3-甲氧基-5-(吡啶-4-基)苯基]丁-1-炔-1-基}嘧啶-2,4-二胺、乙酸根离子、二氢叶酸还原酶等。作者：Reeve, S.M、Anderson, A.C.。存档日期：2014-12-23；发布日期：2016-01-20；最后修改日期：2023-09-27。实验方法：X射线衍射（分辨率2.692 Å）。引用文献：《立体选择性诱导辅因子切换揭示辅因子位点可塑性作为抗叶酸耐药性的潜在机制》（待发表）

创建时间：

2014-12-23