Pharmacokinetics of single dose umeclidinium.
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AUC(0–t) = area under concentration-time curve from time 0 to time of last quantifiable concentration; Cmax = maximum observed plasma concentration; NC = not calculated; tlast = last timepoint where the concentration is above the limit of quantification; tmax = time of maximum observed plasma concentration; UMEC = umeclidinium; VI = Vilanterol;
aSummary statistics derived following Cmax imputation with ½ lower limit of quantification (LLQ) (10 pg/mL) and AUC imputation with ½ lowest observed value for the parameter across treatments;
*Data from two subjects are imputed;
**Data from three subjects are imputed,
†n = 12,
‡n = 13.
bUMEC/VI vs UMEC ratio analysis done without imputing the non-quantifiable (NQ) results.
cPresented as geometric mean and 95% CI.
dPresented as median and range.
创建时间：
2012-12-17
