Pharmacokinetics of single dose umeclidinium.

AUC(0–t) = area under concentration-time curve from time 0 to time of last quantifiable concentration; Cmax = maximum observed plasma concentration; NC = not calculated; tlast = last timepoint where the concentration is above the limit of quantification; tmax = time of maximum observed plasma concentration; UMEC = umeclidinium; VI = Vilanterol; aSummary statistics derived following Cmax imputation with ½ lower limit of quantification (LLQ) (10 pg/mL) and AUC imputation with ½ lowest observed value for the parameter across treatments; *Data from two subjects are imputed; **Data from three subjects are imputed, †n = 12, ‡n = 13. bUMEC/VI vs UMEC ratio analysis done without imputing the non-quantifiable (NQ) results. cPresented as geometric mean and 95% CI. dPresented as median and range.