Private non-synonymous, mt-rRNA and mt-tRNA variants in Chinese LHON mtDNAs with m.14484T>C.

aThe complete mtDNA genomes of Le789, Le1123, Le700 and Le338 contained no private non-synonymous, mt-rRNA, and mt-tRNA variants, and were not included in the table. bThe search was performed on September 13, 2010 following the same strategy described in Bandelt et al. [32], e.g., both ‘A644G mtDNA’ and ‘644A>G mtDNA’ were queried. cThe conservation analysis was performed by comparing Homo sapiens mtDNA (GenBank accession no. J01415) to nine different vertebrate species, Gorilla gorilla (NC_001645), Mus musculus (AY466499), Bos taurus (AY526085), Equus caballus (EF597513), Canis lupus chanco (EU442884), Canis familiaris (DQ480502), Balaenoptera musculus (NC_001601), Rana nigromaculata (AB043889), and Danio rerio (NC_002333). dThe column “Haplogroup-specific variant” refers to the presence or absence of the corresponding variants in the world mtDNA phylogeny displayed at http://www.phylotree.org/tree/main.htm (mtDNA tree Build 10; 10 Aug 2009) [29]. In round brackets we indicated the haplogroup status as it defined in that tree.