Detection of breastmilk antibodies targeting SARS-CoV-2 nucleocapsid, spike and receptor-binding-domain antigens

A 40-year-old female was found to have strongly neutralizing SARS-CoV-2 breastmilk IgA and IgG antibodies reactive against multiple SARS-CoV-2 antigens at 2.5 months after documented infection with SARS-CoV-2. At 6.5 months following the infection, she remained positive for breastmilk and serum SARS-CoV-2 neutralizing antibodies. Holder breast milk pasteurization did not diminish SARS-CoV-2 antibody titres but it reduced its neutralizing capacity, while serum heat inactivation had no negative effect on SARS-CoV-2 serum antibody levels and neutralizing capacity. Current data on SARS-CoV-2 and breastmilk are reviewed.

一名40岁女性在确诊感染新型冠状病毒（SARS-CoV-2）2.5个月后，被检出其母乳中存在针对多种新型冠状病毒（SARS-CoV-2）抗原的强中和性IgA与IgG抗体。感染后6.5个月时，其母乳与血清中的新型冠状病毒中和抗体仍呈阳性。Holder母乳巴氏消毒法未降低新型冠状病毒抗体滴度，但削弱了该抗体的中和活性；而血清热灭活处理对新型冠状病毒血清抗体水平及其中和活性均无负面影响。本文对现有新型冠状病毒与母乳相关的研究数据进行了综述。