lncRNA sequencing in Epilepsy

In the present study, we aimed to determine the expression profile of lncRNAs using a lncRNA library construction and high-throughput sequencing based on a lithium/pilocarpine-induced SE model in immature rats. KEGG and GO analyses were performed to predict the potential function of dysregulated lncRNAs. The hub lncRNAs were determined by weighted correlation network analysis (WGCNA) and their potential function was predicted according to the lncRNA-miRNA-mRNA network. Furthermore, the functional role of a hub lncRNA (NONRATT010788.2) in SE was investigated in an in vitro model.