Rhodium-Catalyzed Annulative Coupling of Isothiazoles with Alkynes through N–S Bond Cleavage
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https://figshare.com/articles/dataset/Rhodium-Catalyzed_Annulative_Coupling_of_Isothiazoles_with_Alkynes_through_N_S_Bond_Cleavage/11474799
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资源简介：
A Rh(III)-catalyzed annulative coupling of 3,5-diarylisothiazoles
and alkynes is reported. The N–S bond in the isothiazole ring
acts as an internal oxidant to regenerate the Rh(III) species in combination
with an external Cu(II) oxidant, and the corresponding 1:2 coupling
products are obtained. The remarkable difference in the reaction outcome
between isothiazoles and the relevant isoxazoles has been investigated
by DFT calculations, revealing that the relative stability of the
enolate intermediates dictates the product selectivity.
创建时间：
2019-12-30
