Temporal resolution of gene derepression and proteome changes upon PROTAC-mediated degradation of BCL11A protein in erythroid cells [ChIP-seq]
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE194342
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We acutely depleted the BCL11A protein by using the dTAG PROTAC technology, and assessed its consequences on histone modification by ChIP-seq,and compared this to changes in nascent transcription, DNA methylation, Protein expression and chromatin accessibility. Examination of changes in histone modification that occur imminently upon depletion of the repressive transcription factor BCL11A.
创建时间:
2022-07-20



