Maternal exposure to bisphenol-A during pregnancy increases pancreatic beta-cell growth during early life in male mice offspring. Mus musculus

Bisphenol-A is a widespread endocrine disruptor chemical. In utero or perinatal exposure to bisphenol-A (BPA), leads to impaired glucose metabolism during adulthood. To investigate the consequences of the exposure to bisphenol-A during development in pancreatic beta-cell growth We used microarrays to determine gene expression changes resulting from exposure to bisphenol-A during pregnancy in pancreatic islets of the male offspring at postnatal day 30. Overall design: Pregnant mice were treated with vehicle or bisphenol-A (10 or 100 μg/kg/day) from day 9 to 16 of gestation. Pancreatic islets were isolated from male offspring at postnatal day 30 (P30). RNA was extracted and hybridized on Affymetrix microarrays.