Binding affinities of ASOs for the oligoribonucleotide targets and SOD-1 minigene mRNA spiked into the nuclear extract.
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Dissociation constants (Kd) were determined as described in the Materials and Methods and figure S3. Differences in the binding affinities (ΔKd) between the two targets were calculated by dividing the Kd of the ASOs for the SOD-1 minigene mRNA spiked into the denatured nuclear extract by the Kd for the oligoribonucleotide targets.
创建时间：
2015-12-02
