Induction of diabetes in P14/RIP-gp and RIP-gp mice using peptide/adjuvant vaccines.

Mice were infused intravenously with indicated peptides and adjuvants on days 0 and 2 and blood was drawn every 2–3 days from the tail vein to assess blood glucose levels for a minimum of 16 days. Diabetes is defined as a blood glucose of >14 mM on two consecutive readings. Indicated results are for at least 5 mice per group and 2–3 independent experiments.