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Synthesis of Fully Substituted Polyhydroxylated Pyrrolizidines via Cope–House Cyclization

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NIAID Data Ecosystem2026-03-07 收录
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Total synthesis of the proposed structure of (−)-hyacinthacine C5 and its epimers at C6 and C7 is described. A key step of the synthesis was the construction of the bicyclic pyrrolizidine system by means of a nucleophilic addition of a dithiane to a cyclic nitrone followed by a Cope–House cyclization.

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2011-08-19
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