Integrated analysis of genomic and epigenomic regulation of transcriptome identifies molecular subtypes of liver cancer (gene expression). Homo sapiens

We profiled DNA copy numbers, DNA methylation, and mRNA expression levels in the same HCC patients. To identify genes which transcriptional expression levels are regulated by genomic and/or epigenetic deregulation, we defined the copy number-correlated and methylation-correlated genes with their corresponding gene expression levels across the samples as genic and epigenetic deregulators, respectively. Overall design: mRNA expression profiling of 64 hepatocellular carcinoma and 30 non-tumor were performed