Crystal structure of the second bromodomain (BD2) of human BRD3 bound to ERK5-IN-1

Crystal structure of the second bromodomain (BD2) of human BRD3 bound to ERK5-IN-1 Descriptor: 11-cyclopentyl-2-({2-ethoxy-4-[4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl]phenyl}amino)-5-methyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one, Bromodomain-containing protein 3 Authors: Karim, M.R, Bikowitz, M.J, Schonbrunn, E. Deposit date: 2021-01-08 Release date: 2021-07-14 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Differential BET Bromodomain Inhibition by Dihydropteridinone and Pyrimidodiazepinone Kinase Inhibitors. J.Med.Chem., 64, 2021

人类BRD3的第二个溴结构域（bromodomain, BD2）与ERK5-IN-1结合的晶体结构。配体描述：11-环戊基-2-({2-乙氧基-4-[4-(4-甲基哌嗪-1-基)哌啶-1-羰基]苯基}氨基)-5-甲基-5,11-二氢-6H-嘧啶并[4,5-b][1,4]苯并二氮杂䓬-6-酮；该蛋白为含溴结构域蛋白3（Bromodomain-containing protein 3）。作者：Karim, M.R、Bikowitz, M.J、Schonbrunn, E。存储日期：2021-01-08；发布日期：2021-07-14；最后修改日期：2023-10-18。实验方法：X射线衍射（分辨率2.7 Å）。引用文献：《Differential BET Bromodomain Inhibition by Dihydropteridinone and Pyrimidodiazepinone Kinase Inhibitors》，刊载于《药物化学杂志》，2021年，第64卷。