DNA-RNA IP sequencing for R-loops in XPO4 Knockout NIH/3T3 cell
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE196317
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资源简介：
Numerous RNAs are exported from the nucleus, abnormalities of which lead to cellular complications and diseases. We report the identification of Exportin 4 (XPO4) as a conserved circular RNA (circRNA) exportin. Cellular insufficiency of XPO4 causes nuclear circRNA accumulation, circRNA:DNA (ciR-loop) formation, linear RNA:DNA (liR-loop) buildup, and DNA damage. These results provide insights into the mechanism and biomedical links of circRNA nuclear export. Examination of R-loops level in NIH/3T3 cells.
创建时间：
2022-10-27
