A system for in vivo ablation of MeCP2-deficient neurons in the Rett Syndrome mouse model

The contents of this file relate to the data generated during the PhD research (Biological Sciences) of Katie Paton, under the supervision of Professor Adrian Bird and Professor Susan Rosser, over the period between September 2020 and December 2021. All data within this file were generated during the aforementioned period, and mainly (but not exclusively) for the purposes of the PhD research and production of the thesis. The data are contained within the main folder “PhD data_Katie Paton”. Within this folder 3 folders can be found: 1) Chapter 3_Mecp2∆DTR-Stop line_generation and characterization; 2) Chapter 4+6_Mecp2∆DTR-FLEx line_generation and characterization; 3) Chapter 5_Transgenic Cre driver_charactisation, each containing the data related to the thesis chapter stated in the name. Within each of the three main folders the data is further categorized into sub-folders, each of which are titled with a brief description of the type of experiment the data addresses. Data files are: images (such as .png .jpg .tif), GraphPad datasets (.pzfx), Excel datasets (.xlsx), DNA sequences (.sbd .dna), flow cytometry data (original .fcs or FlowJo-processed .wsp), imaging files made using specialized software (Zeiss .czi, Leica .lif), Typhoon FLA 7000 phosphoimager data (.gel), Incucyte images and analysis data (.jpg .txt) and others. Further information detailing what data is in each of the three main folders and how it relates to the PhD thesis is provided in .txt files. The PhD thesis is provided as a PDF file for reference and guidance. For any questions, please contact Katie Paton or Adrian Bird. ## Access ## External users may request access to a copy of the data by contacting the Principal Investigator or Contact Person named on this page. University of Edinburgh users who wish to have direct access should consult the information about retrieving data from the DataVault at: http://www.ed.ac.uk/is/research-support/datavault. Requests for access will not necessarily be granted. Some of the data contained in this dataset might become available through other repositories, for example after publication, and subject to the conditions of the respective repositories.