Supplementary Table S13 from A Functional Survey of the Regulatory Landscape of Estrogen Receptor–Positive Breast Cancer Evolution

Supplementary Table S13: Computational predictions of the functional impact of the SNVs and short INDELs identified through SIDV. S13.1: for each variant, the type (SNV or INDEL_short) and its hg38 coordinates are listed, along with the symbol of the nearest gene, and the distance to its TSS in bp (positive or negative values indicate the region is either downstream or upstream the TSS, respectively). Reference and alternative alleles are also provided, along with whether the variant is computationally predicted to alter the molecular function of the genomic element bearing it (indicated as different “pathogenic” classes; column mutation_class) or not (“benign”). The table is then indicating, for each one of the models considered, whether the variant is predicted to significantly affect the indicated molecular function. S13.2: extract of S12.1, for three regions of interest.