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Highly Regio- and Stereoselective Synthesis of Tetrasubstituted Cyclobutenes via Cyclodimerization of Alkynes Mediated by Zirconium

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NIAID Data Ecosystem2026-03-06 收录
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Zirconium-induced cyclodimerization of a variety of heteroaryl-substituted alkynes is described. This method provides a facile synthesis of tetrasubstituted cyclobutenes with high regio- and diastereoselectivity. A ligand-induced reductive elimination mechanism accounting for this novel cyclodimerization is suggested.

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2016-05-06
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