Text S1 - Heat Shock Partially Dissociates the Overlapping Modules of the Yeast Protein-Protein Interaction Network: A Systems Level Model of Adaptation

This supporting information (Text S1) contains a detailed information on the distribution and variabilty of interaction weights, on correlation of mRNA abundances with unweighted degrees and on degree distributions of heat shocked yeast interactomes; a comparison of the metabolic networks of Buchnera aphidicola and Escherichia coli; additional data on the decrease of modular overlap in stresses other than heat shock and using other model parameters; as well as on the topological position of major bridges in the interactome in 8 supporting figures. The supporting information also contains the functional annotation of modules as well as the identity of major proteins with high community centrality and bridgeness values in 4 supporting tables. (PDF)