CD163

The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

该基因编码的蛋白质属于清道夫受体半胱氨酸富集（SRCR）超家族成员，并在单核细胞和巨噬细胞中特异性表达。该蛋白质作为急性期调节性受体，参与巨噬细胞对血红蛋白/触珠蛋白复合物的清除和内吞作用，从而可能保护组织免受游离血红蛋白介导的氧化损伤。此外，该蛋白质还可能作为细菌的天然免疫传感器和局部炎症的诱导剂。该基因已被描述存在不同的剪接转录本变体，编码不同的同种异构体。[由RefSeq提供，2011年8月]