Functional effect of DOT1L pharmacological inhibition in ERα-positive Ovarian Cancer cells

ChEBI2019-11-04 更新2026-07-12 收录

肿瘤靶向治疗

卵巢癌分子机制

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-MTAB-8198 数据链接链接失效反馈

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资源简介：

Functional effect of DOT1L pharmacological inhibition in ERα-positive Ovarian Cancer cells

创建时间：

2019-11-04

SAM Competitive PRMT5 Inhibitor PF-06939999 Demonstrates Antitumor Activity in Splicing Dysregulated NSCLC with Decreased Liability of Drug Resistance

肿瘤靶向治疗

药物耐药机制

Protein arginine methyltransferase 5 (PRMT5) over-expression in hematological and solid tumors methylates arginine residues on cellular proteins involved in important cancer functions including cell c

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Supplementary Tables 1 & 2: GALNT14 regulates ferroptosis and apoptosis of ovarian cancer through EGFR/mTOR pathway

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Supplementary Table 1. GALNT14 regulates ferroptosis and apoptosis of ovarian cancer through EGFR/mTOR pathwayThe clinical characteristics of patients with ovarian cancer Supplementary Table 2. GALN

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Autonomous rhythmic activity in glioma networks drives brain tumor growth

胶质母细胞瘤机制

肿瘤靶向治疗

Glioblastoma cell networks harbor a plastic population of highly active glioblastoma cells that display rhythmic Ca2+ oscillations and are particularly connected to others. Targeting the autonomous rh

NIAID Data Ecosystem40

肿瘤靶分子临床研究信息数据集

肿瘤靶向治疗

临床研究

聚焦肿瘤靶分子临床研究全流程，整合靶点发现、临床试验设计、疗效数据、安全性评估等核心信息。数据经标准化清洗与专业校验，关联靶点分子结构、作用机制及临床结果，支持科研机构靶点验证、药企药物研发、临床机构方案优化，为靶分子临床转化提供高质量、可溯源的数据支撑。

江苏数据交易所80

Uncoupling of PARP1 Trapping and Inhibition Using Selective PARP1 Degradation

PARP抑制剂机制

肿瘤靶向治疗

PARP1 inhibitors (PARPi) are known to kill tumor cells via two mechanisms (i.e., PARP1 catalytic inhibition vs. PARP1 trapping). The relative contribution of these two pathways in mediating the cytoto

NIAID Data Ecosystem70

Functional effect of DOT1L pharmacological inhibition in ERα-positive Ovarian Cancer cells

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