The Zinc Finger Antiviral Protein ZAP Restricts Human Cytomegalovirus and Selectively Binds and Destabilizes Viral UL4/UL5 Transcripts

We describe the influence of the RNA binding protein ZAP (ZC3HAV1) on the CMV gene expression cascade Overall design: PolyA RNA-sequencing and 4su-RNA-seq was performed from CMV infected primary human foreskin fibroblasts and controls, with and without ZAP (ZC3HAV1) knockout, as well as ZAP eCLIP UPDATE: [Feb 22, 2024] The treatment times were corrected from 8hpi to 24hpi in the following Samples: GSM4848747, GSM4848748, GSM4848757, GSM4848758, GSM4848767, GSM4848768, GSM4848777, and GSM4848778.