Advanced glycation end products (AGE) and receptor for AGE (RAGE) in patients with active tuberculosis, and their relationship between food intake and nutritional status

Introduction: The receptor for advanced glycation end products (RAGE) is expressed in normal lungs and is upregulated during infection. AGEs and RAGE cause oxidative stress and apoptosis in lung cells. The objective of this study is to evaluate levels of AGEs and its soluble receptor (sRAGE), and to investigate their relationship with food intake and nutritional status, in a university-affiliated hospital in Brazil. Methods: Case-control study, from June 2017 to June 2018. AGE (carboxymethyl lysine, CML) and sRAGE were measured from blood samples by Elisa. Nutritional assessment was performed by body mass index, triceps skin-fold thickness, mid-arm circumference, mid-arm muscle circumference, bioelectrical impedance analysis, and food frequency questionnaire. Results: We included in the study 35 tuberculosis (TB) patients and 35 controls. The mean sRAGE levels were higher in TB patients than in controls (68.5 ± 28.1 vs 57.5 ± 24.0 pg/mL; p=0.046). Among cases that were current smokers,...研究背景：晚期糖基化终末产物受体（receptor for advanced glycation end products, RAGE）在正常肺组织中表达，并在感染过程中表达上调。晚期糖基化终末产物（advanced glycation end products, AGEs）与其受体RAGE可诱发肺细胞产生氧化应激与细胞凋亡。本研究旨在评估巴西某大学附属医院受试者体内AGEs及其可溶性受体（soluble receptor for advanced glycation end products, sRAGE）的水平，并探讨其与食物摄入及营养状况的关联。 研究方法：本研究为病例对照研究，纳入时间为2017年6月至2018年6月。通过酶联免疫吸附试验（ELISA）检测血液样本中的AGEs（具体为羧甲基赖氨酸，carboxymethyl lysine, CML）与sRAGE水平。营养评估采用身体质量指数、三头肌皮褶厚度、上臂围、上臂肌围、生物电阻抗分析及食物频率问卷进行。 研究结果：本研究共纳入35例结核病（tuberculosis, TB）患者与35例对照人群。结核病患者的sRAGE平均水平显著高于对照组（68.5 ± 28.1 vs 57.5 ± 24.0 pg/mL；p=0.046）。在当前吸烟的病例亚组中……