Prenatally stressed Submissive offspring develop long-term HPA axis dysregualtion.

Sub offspring of PRS pregnancies demonstrated elevated basal serum corticosterone levels (A), alongside reduced hippocampal GR expression (B), while MR expression was reduced among Sub PRS offspring, relative to Dom counterparts (C). GR DNA-binding factor 1 (GRLF1) expression was unchanged by PRS (D).经产前应激（PRS）处理的妊娠个体所产的从属（Sub）子代，其基础血清皮质酮水平升高（图A），同时海马糖皮质激素受体（GR）表达水平降低（图B）；相较于支配（Dom）组子代，该产前应激从属组子代的盐皮质激素受体（MR）表达水平同样下调（图C）。糖皮质激素受体DNA结合因子1（GRLF1）的表达未受PRS的影响（图D）。