Ivermectin and albendazole withdrawal period in goat milk

SUMMARY Theaimthis study was to determine the excretion profile of albendazole and ivermectin residues in milk from goats submitted to antiparasitic treatment. Twenty-four Brazilianmongrel lactating and pluriparous goats, maintained extensively on native pasture were orally treatedwith albendazole or ivermectin. Milk samples were collected before and after vermifuges application, in the days 0, 2, 3 e 4 to albendazole and 0, 3, 7, 14, 21, 28, 35 and 42 to ivermectin. The vermifuges residues were detected by high performance liquid cromatography with ultravioletdetector. The amount of residues contained in themilk was decreasing in function of time. The mean daily rates of decrease of albendazole residues were 63.34%, 40.18 and 100.0%, from the 2ndto the 4thday, respectively; on the 3rdday after treatment, 50% of the samples showed concentrations ≥ 47.61 μg.mL–1, and on the 4thday, no sample had albendazole residue. The amount excreted of ivermectin was similar between the 3rdand 21stday when all samples presented values ≥ 51.90 μg.mL-1; on the 35th day, 50% of the samples showed values above of recommended levels, and on the 42nd day, no sample had detectable ivermectin residue. In conclusion, the milk of Brazilian mongrel goats treated orally with albendazole or ivermectin does not contain its respective residues in detectable amounts from the 4th and 42nddays, respectively, after antiparasitic treatment.

摘要 本研究旨在明确经抗寄生虫治疗的山羊乳汁中阿苯达唑（albendazole）与伊维菌素（ivermectin）残留的排泄特征。选取24头采用天然牧场粗放饲养的巴西混血泌乳经产山羊，分别经口给予阿苯达唑或伊维菌素进行驱虫治疗。分别于给药前后采集乳汁样本：阿苯达唑组的采样时间点为给药后第0、2、3、4天，伊维菌素组的采样时间点为给药后第0、3、7、14、21、28、35及42天。采用紫外检测器高效液相色谱法（high performance liquid chromatography with ultraviolet detector）检测乳汁中的驱虫药残留。结果显示，乳汁中的药物残留量随时间推移呈下降趋势。阿苯达唑残留的日均降解率在给药后第2至4天分别为63.34%、40.18%及100.0%；给药后第3天，50%的样本残留浓度≥47.61 μg·mL⁻¹，至第4天所有样本均未检出阿苯达唑残留。伊维菌素的残留排泄量在给药后第3至21天保持稳定，所有样本残留浓度均≥51.90 μg·mL⁻¹；给药后第35天，50%的样本残留浓度超出推荐安全限值，至第42天所有样本均未检出伊维菌素残留。综上，经口给予阿苯达唑或伊维菌素的巴西混血泌乳山羊，其乳汁分别在给药后第4天和第42天起不再检出对应药物残留。