Sex differences in FGF21-induced changes in hepatic metabolism

To investigate sex-dependent changes in hepatic metabolism in response to fibroblast growth factor-21 (FGF21), we administered FGF21 or vehicle to mice on a high-fat diet then performed gene expression profiling analysis using data obtained from RNA-seq from livers of male and female mice. Comparative gene expression profiling analysis of RNA-seq data from male and female livers in response to FGF21 or saline vehicle (n = 9-11 mice/ group).