The cellular origin and differentiation status of glioblastoma by scRNA-seq. The cellular origin and differentiation status of glioblastoma by scRNA-seq

Understanding the cellular origin and differentiation status of glioblastoma is critical to resolve the etiology of the disease. we profile 18 patient glioblastomas by single cell RNA sequencing (scRNAseq). From this, we uncovered two principal cell-of-origin relations. Each lineage displays unique directional differentiation trajectories and transcriptional cores from the naïve cell populations. Thus, glioblastoma is defined by robust cell lineage features which may provide insights into the cell origin of the diseases. Overall design: Single cell RNA-seq study of human glioblastoma cells *** The raw data has been deposited in the European Genome-phenome Archive (EGAS00001006236) due to patient privacy concerns***